Drug Report History
Below you will find the report version history. When a report is updated, a new version of the report is created. The report history allows you to see the changes between versions. You can select two versions of the report to compare. The fields that were changed between versions will be highlighted in yellow.
The translation of reports creates two separate versions which is why some reports may not seem to have any differences. In this case, only the language field below will be highlighted in yellow.
| Version v15-EN | Version v2-FR | |
|---|---|---|
| Language | English | French |
| Date Updated | 2025-02-18 | 2024-11-22 |
| Drug Identification Number | 02147440 | 02147440 |
| Brand name | ACTIVASE RT-PA | ACTIVASE RT-PA |
| Common or Proper name | ALTEPLASE | ALTEPLASE |
| Company Name | HOFFMANN-LA ROCHE LIMITED | HOFFMANN-LA ROCHE LIMITED |
| Ingredients | WATER ALTEPLASE | WATER ALTEPLASE |
| Strength(s) | 100ML 100MG | 100ML 100MG |
| Dosage form(s) | POWDER FOR SOLUTION LIQUID | POWDER FOR SOLUTION LIQUID |
| Route of administration | INTRAVENOUS INTRAVENOUS | INTRAVENOUS INTRAVENOUS |
| Packaging size | 1x 100MG VIAL | 1x 100MG VIAL |
| ATC code | B01AD | B01AD |
| ATC description | ANTITHROMBOTIC AGENTS | ANTITHROMBOTIC AGENTS |
| Reason for shortage | Disruption of the manufacture of the drug. | Disruption of the manufacture of the drug. |
| Anticipated start date | 2025-02-17 | 2024-12-20 |
| Actual start date | ||
| Estimated end date | 2025-07-14 | 2025-01-31 |
| Actual end date | ||
| Shortage status | Actual shortage | Anticipated shortage |
| Tier 3 Status | No | No |
| Company comments | We regret to inform you that Roche Canada is experiencing supply constraints for Activase 100 mg. As a result, we will be out of stock for Activase 100 mg starting mid-February, with resupply expected around mid-year in July. Please note that this shortage does not impact the supply of Activase 50 mg, which will continue to be available. If you require urgent assistance regarding supply please contact Order and Distribution Management: mississauga.order_mgmt@roche.com or through the CPDN portal. | We are operating at 70% supply allocation until further notice. This will ensure equitable access for patients and mitigate any potential supply constraints for hospitals. If you require urgent assistance regarding Activase 100 supply please contact Order and Distribution Management: mississauga.order_mgmt@roche.com or through the CPDN portal. |
| Health Canada comments |